Ethylamine → HCID 66723404, compound

HRID 1806426Notes

Reaction equation

HRID 1806426 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([NH:10][CH2:11][C:12]1[CH:13]=[C:14]([C:19]2[CH:20]=[C:21]3[C:25](=[C:26]([C:28]([NH2:30])=[O:29])[CH:27]=2)[NH:24][CH:23]=[C:22]3[CH:31]2[CH2:36][CH2:35][N:34]([S:37]([CH2:40][CH3:41])(=[O:39])=[O:38])[CH2:33][CH2:32]2)[CH:15]=[CH:16][C:17]=1[F:18])[CH3:9].[CH2:42](N)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]1([NH:10][CH2:11][C:12]2[CH:13]=[C:14]([C:19]3[CH:20]=[C:21]4[C:25](=[C:26]([C:28]([NH2:30])=[O:29])[CH:27]=3)[NH:24][CH:23]=[C:22]4[CH:31]3[CH2:32][CH2:33][N:34]([S:37]([CH2:40][CH3:41])(=[O:39])=[O:38])[CH2:35][CH2:36]3)[CH:15]=[CH:16][C:17]=2[F:18])[CH2:42][CH2:9]1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 66723146HCID 66723146, compound

Product 1

HCID 66723404HCID 66723404, compoundYield 49.4%

Procedure

The title compound was prepared according to the general procedure of 5-{3-[(ethylamino)methyl]-4-fluorophenyl}-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide trifluoroacetate, substituting cyclopropylamine (32 mg, 0.46 mmol) for ethylamine to afford 23 mg of the title compound (49.4%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-e0c4603d489646f48d3bc550f8fd9cc7
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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