(2-Thienylmethyl)amine → HCID 66723411, compound

HRID 1806440Notes

Reaction equation

HRID 1806440 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:42]([NH2:44])=[O:43])[CH:24]=[C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][NH:35][CH2:36][C:37]5S[CH:39]=[CH:40][CH:41]=5)[CH:29]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9].S1C=CC=C1CN>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:42]([NH2:44])=[O:43])[CH:24]=[C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][NH:35][CH2:36][C@@H:37]5[CH2:41][CH2:40][CH2:39][O:4]5)[CH:29]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:11])=[O:12])[CH3:9]

Participants

3

Reactant 2

HCID 34005(2-Thienylmethyl)amineHCID 66722837HCID 66722837, compound

Product 1

HCID 66723411HCID 66723411, compoundYield 74.7%

Procedure

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-{[(2-thienylmethyl)amino]methyl}phenyl)-1H-indole-7-carboxamide trifluoroacetate, substituting 1-[(2S)-tetrahydro-2-furanyl]methanamine (31.5 mg, 0.6 mmol) for 1-(2-thienyl)methanamine to afford 39.2 mg of the title compound (74.7%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-44c90dcb829e4021849e9cb4ee63cb1d
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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