(2-Thienylmethyl)amine → HCID 66723153, compound

HRID 1806441Notes

Reaction equation

HRID 1806441 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:42]([NH2:44])=[O:43])[CH:24]=[C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][NH:35][CH2:36]C5SC=CC=5)[CH:29]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9].S1[CH:49]=[CH:48][CH:47]=C1CN>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:2][C:48]([CH3:47])([CH3:49])[CH2:36][NH:35][CH2:34][C:30]1[CH:29]=[C:28]([C:25]2[CH:26]=[C:27]3[C:22](=[C:23]([C:42]([NH2:44])=[O:43])[CH:24]=2)[NH:21][CH:20]=[C:19]3[CH:16]2[CH2:15][CH2:14][N:13]([S:10]([CH2:8][CH3:9])(=[O:11])=[O:12])[CH2:18][CH2:17]2)[CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 34005(2-Thienylmethyl)amineHCID 66722837HCID 66722837, compound

Product 1

HCID 66723153HCID 66723153, compoundYield 59.5%

Procedure

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-{[(2-thienylmethyl)amino]methyl}phenyl)-1H-indole-7-carboxamide trifluoroacetate, substituting 2,2-dimethyl-1-propanamine (30.6 mg, 0.6 mmol) for 1-(2-thienyl)methanamine to afford 30.4 mg of the title compound (59.5%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-dc658f3d0b264ff4bdfa9062030a7164
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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