HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-Tetrahydrofurfurylamine → HCID 66723372, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-Tetrahydrofurfurylamine | HCID 641530 | — |
| Reactant | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate | HCID 66723136 | — |
| Product | HCID 66723372 | HCID 66723372 | 68.7% |
Reaction Steps
The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 1-(tetrahydro-2H-pyran-4-yl)methanamine (60 mg, 0.525 mmol) for 1-[(2S)-tetrahydro-2-furanyl]methanamine to afford 40.1 mg of the title compound (68.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354406B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0b9e60ee00da4a67a1ae3bab084f34b8 |
| Source note | uspto-grants-2013_01 |