Isobutylamine → HCID 42630735, compound

HRID 1806468Notes

Reaction equation

HRID 1806468 reaction equation
F[C:2](F)(F)[C:3](O)=O.[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:39]([NH2:41])=[O:40])[CH:24]=[C:25]([C:28]4[N:29]=[C:30]([CH2:33][NH:34][CH2:35]C(C)C)[S:31][CH:32]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9].[CH3:42][CH:43](C)CN>>[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:39]([NH2:41])=[O:40])[CH:24]=[C:25]([C:28]4[N:29]=[C:30]([CH2:33][N:34]5[CH2:35][CH2:3][CH2:2][CH2:43][CH2:42]5)[S:31][CH:32]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9]

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 66723627HCID 66723627, compound

Product 1

HCID 42630735HCID 42630735, compoundYield 51.6%

Procedure

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(2-{[(2-methylpropyl)amino]methyl}-1,3-thiazol-4-yl)-1H-indole-7-carboxamide trifluoroacetate, substituting piperidine (78 mg, 0.3 mmol) for 2-methyl-1-propanamine to afford 15.5 mg of the title compound (51.6%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-25875da272354c438579826847a1b1cf
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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