Dimethylamine → HCID 66722950, compound

HRID 1806469Notes

Reaction equation

HRID 1806469 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH2:11][C:12]1[S:13][CH:14]=[C:15]([C:17]2[CH:18]=[C:19]3[C:23](=[C:24]([C:26]([NH2:28])=[O:27])[CH:25]=2)[NH:22][CH:21]=[C:20]3[CH:29]2[CH2:34][CH2:33][N:32]([S:35]([CH2:38][CH3:39])(=[O:37])=[O:36])[CH2:31][CH2:30]2)[N:16]=1)[CH3:10].[CH3:40]NC>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:10]([N:9]([CH2:11][C:12]1[S:13][CH:14]=[C:15]([C:17]2[CH:18]=[C:19]3[C:23](=[C:24]([C:26]([NH2:28])=[O:27])[CH:25]=2)[NH:22][CH:21]=[C:20]3[CH:29]2[CH2:34][CH2:33][N:32]([S:35]([CH2:38][CH3:39])(=[O:37])=[O:36])[CH2:31][CH2:30]2)[N:16]=1)[CH3:8])[CH3:40]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 66723357HCID 66723357, compound

Product 1

HCID 66722950HCID 66722950, compoundYield 60.4%

Procedure

The title compound was prepared according to the general procedure of 5-{2-[(dimethylamino)methyl]-1,3-thiazol-4-yl}-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide trifluoroacetate, substituting ethyl(methyl)amine (73 mg, 0.3 mmol) for dimethylamine to afford 25 mg of the title compound (60.4%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ff9bc62fc1fd45108a9adc6a8f60b7c5
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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