Prolinol, (R)- → 5-(5-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Prolinol, (R)-	HCID 2724541	—
Reactant	5-(5-{[(2R)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide	HCID 57732666	—
Product	5-(5-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide	HCID 57732685	51.9%

Reaction Steps

The title compound was prepared according to the general procedure of 5-(5-{[(2R)-2-(hydroxymethyl)-1-pyrrolidinyl]methyl}-3-thienyl)-3-{1-[(1-methylethyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide, substituting 2-(methylamino)ethanol (90.13 mg, 1.20 mmol) for (2R)-2-pyrrolidinylmethanol to afford 8 mg of the title compound (51.9%),

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354406B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-97b6c274119845b6a0062c7394b63de2
Source note	uspto-grants-2013_01