Sec-Butylamine → HCID 57732748, compound

HRID 1806501Notes

Reaction equation

[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[C:16]([C:33]([NH2:35])=[O:34])[CH:17]=[C:18]([C:21]4[CH:25]=[C:24]([CH2:26][N:27]([CH3:32])[CH:28]([CH3:31])CC)[S:23][CH:22]=4)[CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].[CH2:36]([O:38]CCN)[CH3:37].CC(N)CC>>[CH2:36]([O:38][CH2:31][CH2:28][N:27]([CH2:26][C:24]1[S:23][CH:22]=[C:21]([C:18]2[CH:19]=[C:20]3[C:15](=[C:16]([C:33]([NH2:35])=[O:34])[CH:17]=2)[NH:14][CH:13]=[C:12]3[CH:9]2[CH2:8][CH2:7][N:6]([S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]2)[CH:25]=1)[CH3:32])[CH3:37]

Participants

Reactant 3

HCID 24874Sec-Butylamine

HCID 66970Ethoxyethylamine

HCID 57732871HCID 57732871, compound

Product 1

HCID 57732748HCID 57732748, compoundYield 11.5%

Procedure

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-{[methyl(1-methylpropyl)amino]methyl}-3-thienyl)-1H-indole-7-carboxamide, substituting 2-(ethyloxy)ethanamine (1 mmol) for added 2-butanamine to afford 6.1 mg of the title compound (11.5%).

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-da176d82dd07401db91ad1dfee3066bc
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354406B2

Reaction notes

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