HRID1806535

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1268291

4-Amino-1-Boc-piperidine

C10H20N2O2

结构：Cc1ccc(NC(=O)c2ccc(Cl)nc2)cc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F

HCID59212686

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(Cl)nc2)cc1-c1nc(NC2CCNCC2)nc2c1ccc(=O)n2-c1c(F)cccc1F

HCID11947851

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 2 from 6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamide and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate: LC-MS m/z 602 (M+H)+, 1.75 min (ret time).

WORKUP

后处理

customLC-MS m/z 602 (M+H)+, 1.75 min (ret time)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b75cd48eef674dcd8ab2d23d1eb8f652
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354416B2
来源说明: uspto-grants-2013_01

反应 SMILES

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([C:18]3[C:19]4[CH:31]=[CH:30][C:29](=[O:32])[N:28]([C:33]5[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=5[F:40])[C:20]=4[N:21]=[C:22](S(C)(=O)=O)[N:23]=3)[CH:12]=2)=[O:9])=[CH:4][CH:3]=1.[NH2:41][CH:42]1[CH2:47][CH2:46][N:45](C(OC(C)(C)C)=O)[CH2:44][CH2:43]1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([C:18]3[C:19]4[CH:31]=[CH:30][C:29](=[O:32])[N:28]([C:33]5[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=5[F:40])[C:20]=4[N:21]=[C:22]([NH:41][CH:42]4[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]4)[N:23]=3)[CH:12]=2)=[O:9])=[CH:4][CH:3]=1