HRID1806537

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID37524

2,2,6,6-Tetramethylpiperidin-4-amine

C9H20N2

结构：Cc1ccc(NC(=O)c2ccc(Cl)nc2)cc1-c1nc(S(C)(=O)=O)nc2c1ccc(=O)n2-c1c(F)cccc1F

HCID59212686

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(Cl)nc2)cc1-c1nc(NC2CC(C)(C)NC(C)(C)C2)nc2c1ccc(=O)n2-c1c(F)cccc1F

HCID11947853

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1d from 6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamide and 2,2,6,6-tetramethyl-4-piperidinamine: LC-MS m/z 658 (M+H)+, 1.92 min (ret time).

WORKUP

后处理

customLC-MS m/z 658 (M+H)+, 1.92 min (ret time)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e483b9a62994465686565a71bd9c129b
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354416B2
来源说明: uspto-grants-2013_01

反应 SMILES

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([C:18]3[C:19]4[CH:31]=[CH:30][C:29](=[O:32])[N:28]([C:33]5[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=5[F:40])[C:20]=4[N:21]=[C:22](S(C)(=O)=O)[N:23]=3)[CH:12]=2)=[O:9])=[CH:4][CH:3]=1.[CH3:41][C:42]1([CH3:51])[CH2:47][CH:46]([NH2:48])[CH2:45][C:44]([CH3:50])([CH3:49])[NH:43]1>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([C:18]3[C:19]4[CH:31]=[CH:30][C:29](=[O:32])[N:28]([C:33]5[C:38]([F:39])=[CH:37][CH:36]=[CH:35][C:34]=5[F:40])[C:20]=4[N:21]=[C:22]([NH:48][CH:46]4[CH2:47][C:42]([CH3:51])([CH3:41])[NH:43][C:44]([CH3:50])([CH3:49])[CH2:45]4)[N:23]=3)[CH:12]=2)=[O:9])=[CH:4][CH:3]=1