4-Amino-1-Boc-piperidine → 4-(5-amino-methylphenyl)-8-(2,6-difluorophenyl)-2-(4-piperidinylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one

HRID 1806593Notes

Reaction equation

HRID 1806593 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=4[F:30])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)[CH:7]=1.[NH2:32][CH:33]1[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]1>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=4[F:30])[C:10]=3[N:11]=[C:12]([NH:32][CH:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)[N:13]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 592126804-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 592127534-(5-amino-methylphenyl)-8-(2,6-difluorophenyl)-2-(4-piperidinylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one

Procedure

The title compound was prepared as described in Example 2 from 4-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate. LC-MS m/z 463 (M+H)+, 1.73 min (ret time).

Workup

  1. customLC-MS m/z 463 (M+H)+, 1.73 min (ret time)

Sources & evidence

ORD record
ord-50a20158cf034223bbe1785835f84eb7
Source dataset
uspto-grants-2013_01
Patent number
US08354416B2

Reaction notes

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