3,3-Dimethylbutanal → HCID 178444818, compound

HRID 1806676Notes

Reaction equation

HRID 1806676 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]([CH3:16])([CH3:15])[CH2:12][CH:13]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:13]/[CH2:12][C:11]([CH3:16])([CH3:15])[CH3:10])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 763353,3-DimethylbutanalHCID 151417Glycine tert-butyl ester

Product 1

HCID 178444818HCID 178444818, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of glycine tert-butyl ester (Alfa) (2.71 g, 20.0 mmol) and 3,3-dimethyl-butyraldehyde (Alfa) (2.21 g, 21.0 mmol) in CH2Cl2 (50 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried in vacuo to give [3,3-dimethyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester (4.29 g, 100%) as colorless oil which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-8310a32c1b0547eb9d7a3beb1f45f646
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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