Glycine tert-butyl ester → HCID 178451246, compound

HRID 1806728Notes

Reaction equation

HRID 1806728 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:10]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][CH2:12][CH2:11]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:16]/[CH2:15][CH:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 124898662-Cyclopentylacetaldehyde

Product 1

HCID 178451246HCID 178451246, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.7 g, 5 mmol) was reacted with 2-cyclopentylacetaldehyde (Betapharma) (0.9 g, 8 mmol) in CH2Cl2 at room temperature for 20 h to give [2-cyclopentyl-eth-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1 g, 90%).

Sources & evidence

ORD record
ord-33618719ee204559976c41c7bc3b595f
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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