2-Ethylbutyraldehyde → HCID 178449147, compound

HRID 1806743Notes

Reaction equation

HRID 1806743 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:10]([CH:12]([CH2:15][CH3:16])[CH:13]=O)[CH3:11]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:13]/[CH:12]([CH2:15][CH3:16])[CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 73592-EthylbutyraldehydeHCID 151417Glycine tert-butyl ester

Product 1

HCID 178449147HCID 178449147, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with 2-ethylbutyraldehyde (Aldrich) (0.55 g, 5 mmol) in CH2Cl2 at room temperature for 18 h to give [2-ethyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1 g, 94%).

Sources & evidence

ORD record
ord-c94993f32db84474acceb375332f4f4b
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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