Isobutyraldehyde → HCID 178449146, compound

HRID 1806754Notes

Reaction equation

HRID 1806754 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:10](=O)[CH:11]([CH3:13])[CH3:12]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:10]/[CH:11]([CH3:13])[CH3:12])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6561IsobutyraldehydeHCID 151417Glycine tert-butyl ester

Product 1

HCID 178449146HCID 178449146, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with isobutyraldehyde (Aldrich) (0.4 g, 5 mmol) in CH2Cl2 at room temperature for 20 h to give [2-methyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (0.9 g, 97%).

Sources & evidence

ORD record
ord-4d66f332bcf84662ab272d6d693d623c
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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