Cyclohexanecarboxaldehyde → HCID 178451233, compound

HRID 1806758Notes

Reaction equation

HRID 1806758 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:10]1([CH:16]=O)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:16]/[CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 151417Glycine tert-butyl ester

Product 1

HCID 178451233HCID 178451233, compoundYield 106.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with cyclohexanecarbaldehyde (Aldrich) (0.6 g, 5 mmol) in CH2Cl2 at room temperature for 20 h to give {[1-cyclohexyl-meth-(E)-ylidene]-amino}-acetic acid tert-butyl ester as a colorless oil (1.2 g, 100%).

Sources & evidence

ORD record
ord-650cc42e3a4d470cae52f2d59df69206
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

Loading…