Benzeneacetonitrile, 4-fluoro- → HCID 59249604, compound

Participants

Reaction Steps

In a manner similar to the method described in Example 1b, 4-fluorophenylacetonitrile (Aldrich) (3.5 g, 26 mmol) was reacted with 3-chloro-2-fluorobenzaldehyde (5.3 g, 34 mmol), methanolic solution (25 wt %) of sodium methoxide (15 mL, 66 mmol) in methanol (200 mL) at 50° C. for 3 h to give (Z)-3-(3-chloro-2-fluoro-phenyl)-2-(4-fluoro-phenyl)-acrylonitrile as a white powder (5.7 g, 80%).

Provenance & Evidence