HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 2-(4-Chloro-2-methoxyphenyl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 4-Chloro-1-(chloromethyl)-2-methoxybenzene | HCID 18523560 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Chloro-2-methoxyphenyl)acetonitrile | HCID 22327524 | 36.7% |
Reaction Steps
Step B In a manner similar to the method described in Example 57 Step B, 4-chloro-2-methoxybenzyl chloride (5.1 g, 27 mmol) was reacted with NaCN (3 g, 61 mmol) in ethanol (40 mL) and water (20 mL) at 100° C. for 8 h to give 4-chloro-2-methoxybenzyl cyanide as a colorless oil (1.8 g, 36%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354444B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-63d99f0dddee4c84a99ab6a01ccd95eb |
| Source note | uspto-grants-2013_01 |