Glycine tert-butyl ester → HCID 178443624, compound

HRID 1806852Notes

Reaction equation

HRID 1806852 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]([CH3:18])([CH:15]([CH3:17])[CH3:16])[CH2:12][CH:13]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:13]/[CH2:12][C:11]([CH3:18])([CH3:10])[CH:15]([CH3:17])[CH3:16])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 124253353,3,4-Trimethylpentanal

Product 1

HCID 178443624HCID 178443624, compoundYield 80.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step D In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1 g, 7.7 mmol) was reacted with 3,3,4-trimethyl-pentanal (1.1 g, 8 mmol) in CH2Cl2 at room temperature for 5 h to give [3,3,4-trimethyl-pent-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.5 g, 80%).

Sources & evidence

ORD record
ord-110f75357df64c9490e40fd8f9ab3abb
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

Loading…