Glycine tert-butyl ester → HCID 178443985, compound

HRID 1806857Notes

Reaction equation

HRID 1806857 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]([CH3:17])([CH:15]=[CH2:16])[CH2:12][CH:13]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:16]/[CH2:15][C:11]([CH3:17])([CH3:10])[CH:12]=[CH2:13])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 129170803,3-Dimethylpent-4-enal

Product 1

HCID 178443985HCID 178443985, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.3 g, 10 mmol) was reacted with 3,3-dimethyl-pent-4-enal (1.2 g, 11 mmol) in CH2Cl2 at room temperature for 18 h to give [3,3-dimethyl-pent-4-en-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (2.1 g, 93%).

Sources & evidence

ORD record
ord-d27e5690eb59400d91160aec70605091
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

Loading…