HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → 4-Chloro-2-methylbenzeneacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 4-Chloro-1-(chloromethyl)-2-methylbenzene | HCID 12822618 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-2-methylbenzeneacetonitrile | HCID 18409934 | 72.5% |
Reaction Steps
Step B In a manner similar to the method described in Example 57 Step B, 4-chloro-2-methylbenzyl chloride (1.83 g, 10 mmol) was reacted with KCN (1.76 g, 27 mmol) in ethanol (13 mL) and water (10 mL) at 100° C. for 1 h to give 4-chloro-2-methylbenzyl cyanide as a yellow oil (1.2 g, 69%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354444B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0285d8a9d5ba420bb55abaaaa371b96e |
| Source note | uspto-grants-2013_01 |