Glycine tert-butyl ester → HCID 178428540, compound

HRID 1806911Notes

Reaction equation

HRID 1806911 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]1([CH2:17][CH:18]=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:18]/[CH2:17][C:11]1([CH3:10])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 12721744HCID 12721744, compound

Product 1

HCID 178428540HCID 178428540, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step E In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.87 g, 14.3 mmol) was reacted with (1-methyl-cyclohexyl)-acetaldehyde (2.9 g, 14.3 mmol) in CH2Cl2 at room temperature for 18 h to give [2-(1-methyl-cyclohexyl)-eth-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (3.4 g, 95%).

Sources & evidence

ORD record
ord-ff0019d48cab4131ad0cd9ed5589d486
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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