Glycine tert-butyl ester → HCID 178500290, compound

HRID 1806925Notes

Reaction equation

HRID 1806925 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][O:11][C:12](=[O:19])[C:13]([CH3:18])([CH3:17])[CH2:14][CH:15]=O>C(Cl)Cl>[CH3:10][O:11][C:12](=[O:19])[C:13]([CH3:18])([CH3:17])[CH2:14]/[CH:15]=[N:8]/[CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:9]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 13639029Methyl 2,2-dimethyl-4-oxobutanoate

Product 1

HCID 178500290HCID 178500290, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step D In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.09 g, 8.32 mmol) was reacted with 2,2-dimethyl-4-oxo-butyric acid methyl ester (1.2 g, 8.32 mmol) in CH2Cl2 at room temperature for 18 h to give 4-[(E)-tert-butoxycarbonylmethylimino]-2,2-dimethyl-butyric acid methyl ester as a colorless oil (2.1 g, 100%).

Sources & evidence

ORD record
ord-93394aede59c4359b35407b278b5a7b3
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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