Glycine tert-butyl ester → HCID 178443501, compound

HRID 1806941Notes

Reaction equation

HRID 1806941 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:10]([C:12]([CH2:18][CH3:19])([CH2:16][CH3:17])[CH2:13][CH:14]=O)[CH3:11]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:11]/[CH2:10][C:12]([CH2:18][CH3:19])([CH2:16][CH3:17])[CH2:13][CH3:14])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 141957023,3-Diethyl-pentanal

Product 1

HCID 178443501HCID 178443501, compoundYield 100.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step F In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.92 g, 7 mmol) was reacted with 3,3-diethyl-pentanal (1 g, 7 mmol) in CH2Cl2 at room temperature for 5 h to give [3,3-diethyl-pent-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.8 g, 100%).

Sources & evidence

ORD record
ord-7fe7b01bc9bb4944a6ce02961934a227
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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