Glycine tert-butyl ester → HCID 178443625, compound

HRID 1806949Notes

Reaction equation

HRID 1806949 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:10]([C:12]([CH3:18])([CH2:16][CH3:17])[CH2:13][CH:14]=O)[CH3:11]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:11]/[CH2:10][C:12]([CH2:16][CH3:17])([CH3:18])[CH2:13][CH3:14])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 126139583-Ethyl-3-methyl-pentanal

Product 1

HCID 178443625HCID 178443625, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step E In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.0 g, 7.8 mmol) was reacted with 3-ethyl-3-methyl-pentanal (1 g, 7.8 mmol) in CH2Cl2 at room temperature for 5 h to give [3-ethyl-3-methyl-pent-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.9 g, 100%).

Sources & evidence

ORD record
ord-3c5299d5882e4b1a8ae1a5632ef52ac6
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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