Glycine tert-butyl ester → HCID 178494953, compound

HRID 1806965Notes

Reaction equation

HRID 1806965 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][O:11][CH2:12][C:13]([CH3:18])([CH3:17])[CH2:14][CH:15]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:15]/[CH2:14][C:13]([CH3:18])([CH3:17])[CH2:12][O:11][CH3:10])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 87344610HCID 87344610, compound

Product 1

HCID 178494953HCID 178494953, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step E In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.3 g, 2.3 mmol) was reacted with 4-methoxy-3,3-dimethyl-butyraldehyde (0.3 g, 2.3 mmol) in CH2Cl2 at room temperature for 18 h to give [4-methoxy-3,3-dimethyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (0.56 g, 100%).

Sources & evidence

ORD record
ord-0b03f42f6c6b44188eee66a46025ed0a
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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