Dichloromethane → HCID 178494953, compound

HRID 1806972Notes

Reaction equation

HRID 1806972 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].C([SiH2][O:15][C:16](C)(C)[C:17]([CH2:23]C)([CH2:21]C)[CH2:18][CH:19]=O)(C)(C)C.[CH2:27](Cl)Cl>>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:19]/[CH2:18][C:17]([CH3:23])([CH3:21])[CH2:16][O:15][CH3:27])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 151417Glycine tert-butyl esterHCID 131730159HCID 131730159, compound

Product 1

HCID 178494953HCID 178494953, compoundYield 100%

Procedure

Step E In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.78 g, 5.8 mmol) was reacted with 3-(tert-butyl-dimethyl-silanyloxymethyl)-3-ethyl-pentanal (1.5 g, 5.8 mmol) in CH2Cl2 at room temperature for 18 h to give [4-methoxy-3,3-dimethyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (2.2 g, 100%).

Sources & evidence

ORD record
ord-7b9acf804d734ac38e952c252679d01f
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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