Glycine tert-butyl ester → HCID 178428541, compound

HRID 1806976Notes

Reaction equation

HRID 1806976 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]1([CH2:15][CH:16]=O)[CH2:14][O:13][CH2:12]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:16]/[CH2:15][C:11]1([CH3:10])[CH2:14][O:13][CH2:12]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 840819811219088-56-8

Product 1

HCID 178428541HCID 178428541, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step D In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.92 g, 7 mmol) was reacted with (3-methyl-oxetan-3-yl)-acetaldehyde (0.8 g, 7 mmol) in CH2Cl2 at room temperature for 18 h to give [2-(3-methyl-oxetan-3-yl)-eth-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.6 g, 100%).

Sources & evidence

ORD record
ord-e724138c1ca045fa89d663befba40d9d
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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