Glycine tert-butyl ester → HCID 178436812, compound

HRID 1806980Notes

Reaction equation

HRID 1806980 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:10]([C:12]1([CH2:16][CH:17]=O)[CH2:15][O:14][CH2:13]1)[CH3:11]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:11]/[CH2:10][C:12]1([CH2:16][CH3:17])[CH2:15][O:14][CH2:13]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 84081982HCID 84081982, compound

Product 1

HCID 178436812HCID 178436812, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step B In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1 g, 7.8 mmol) was reacted with (3-ethyl-oxetan-3-yl)-acetaldehyde (1 g, 7.8 mmol) in CH2Cl2 at room temperature for 18 h to give [2-(3-ethyl-oxetan-3-yl)-eth-(E)-ylideneamino]-acetic acid tert-butyl ester as a yellow oil (1.9 g, 100%).

Sources & evidence

ORD record
ord-84def9485cb74332a3cf04862adc7efd
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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