Dichloromethane → HCID 178451248, compound

HRID 1806991Notes

Reaction equation

[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[C:10]([SiH2:14][O:15][C:16]([CH3:26])([CH3:25])[C:17]1([CH:23]=O)[CH2:22][CH2:21][CH:20]=[CH:19][CH2:18]1)([CH3:13])([CH3:12])[CH3:11].[CH2:27](Cl)Cl>>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:27]/[CH2:23][C:17]1([C:16]([CH3:26])([CH3:25])[O:15][SiH2:14][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:22][CH2:21][CH:20]=[CH:19][CH2:18]1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 151417Glycine tert-butyl ester

HCID 131730164HCID 131730164, compound

Product 1

HCID 178451248HCID 178451248, compoundYield 100%

Procedure

Step B In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.2 g, 9 mmol) was reacted with 1-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enecarbaldehyde (2.5 g, 9 mmol) in CH2Cl2 at room temperature for 18 h to give [2-[1-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enyl]-eth-(E)-ylideneamino]-acetic acid tert-butyl ester as a light yellow oil (3.5 g, 100%).

Sources & evidence

ORD record: ord-2a1ec81e41e14ef5a0b704796f279e3c
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354444B2

Reaction notes

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