Glycine tert-butyl ester → HCID 178446420, compound

HRID 1807000Notes

Reaction equation

HRID 1807000 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[C:10]([Si:14]([CH3:28])([CH3:27])[O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][C:21]([CH3:26])([CH3:25])[CH2:22][CH:23]=O)([CH3:13])([CH3:12])[CH3:11]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:23]/[CH2:22][C:21]([CH3:25])([CH3:26])[CH2:20][CH2:19][O:18][CH2:17][CH2:16][O:15][Si:14]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:27])[CH3:28])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 866404205-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,3-dimethyl-pentanal

Product 1

HCID 178446420HCID 178446420, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step C In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.13 g, 1 mmol) was reacted with 5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,3-dimethyl-pentanal (0.27 g, 1 mmol) in CH2Cl2 at room temperature for 18 h to give [5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,3-dimethyl-pent-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (0.4 g, 100%).

Sources & evidence

ORD record
ord-a0f09ac085274de09f3fdc8661c97d43
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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