Glycine tert-butyl ester → HCID 178446419, compound

HRID 1807008Notes

Reaction equation

HRID 1807008 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[N:10]([CH2:13][CH2:14][C:15]([CH3:20])([CH3:19])[CH2:16][CH:17]=O)=[N+:11]=[N-:12]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:17]/[CH2:16][C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][N:10]=[N+:11]=[N-:12])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 866404265-Azido-3,3-dimethyl-pentanal

Product 1

HCID 178446419HCID 178446419, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step C In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.32 g, 2.45 mmol) was reacted with 5-azido-3,3-dimethyl-pentanal (0.38 g, 2.45 mmol) in CH2Cl2 at room temperature for 18 h to give [5-azido-3,3-dimethyl-pent-(E)-ylideneamino]-acetic acid tert-butyl ester as a yellow oil (0.65 g, 100%).

Sources & evidence

ORD record
ord-3f6b3d1f27424755946b75790209f91b
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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