Glycine tert-butyl ester → HCID 178451252, compound

HRID 1807038Notes

Reaction equation

HRID 1807038 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:10]([N:17]1[CH2:22][CH:21]=[C:20]([C:23]([CH3:28])([CH3:27])[CH2:24][CH:25]=O)[CH2:19][CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:25]/[CH2:24][C:23]([C:20]1[CH2:21][CH2:22][N:17]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:18][CH:19]=1)([CH3:28])[CH3:27])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 866404423-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-3-methyl-butyraldehyde

Product 1

HCID 178451252HCID 178451252, compoundYield 101.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step F In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.84 g, 6.4 mmol) was reacted with 3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-3-methyl-butyraldehyde (1.65 g, 6.4 mmol) in CH2Cl2 at room temperature for 5 h to give [3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-3-methyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a yellow oil (2.4 g, 100%).

Sources & evidence

ORD record
ord-d1a21db0b0054bc8a766d0be84a5c575
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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