Glycine tert-butyl ester → HCID 178451253, compound

HRID 1807049Notes

Reaction equation

HRID 1807049 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[O:10]1[CH2:15][CH:14]=[C:13]([C:16]([CH3:21])([CH3:20])[CH2:17][CH:18]=O)[CH2:12][CH2:11]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:18]/[CH2:17][C:16]([C:13]1[CH2:14][CH2:15][O:10][CH2:11][CH:12]=1)([CH3:21])[CH3:20])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 866404483-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-butyraldehyde

Product 1

HCID 178451253HCID 178451253, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step F In a manner similar to the method described in Example 1a, glycine tert-butyl ester (2 g, 15.5 mmol) was reacted with 3-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-butyraldehyde (2.6 g, 15.5 mmol) in CH2Cl2 at room temperature for 5 h to give [3-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a yellow oil (4.3 g, 100%).

Sources & evidence

ORD record
ord-e2d16fe2121e4d2bb7298aaa08dc7925
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

Loading…