HCID 86640474, compound → HCID 59249306, compound

Participants

Reaction Steps

Rac (2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid (6-oxo-1,6-dihydro-pyridin-3-yl)-amide (168 mg) was resolved on a Berger SFC machine under 100 bar, 30° C. with 40% of methanol at a rate of 2 mL/min give two separated peaks. Peak 1, 62 mg (desired), peak 2, 64 mg (undesired).

Provenance & Evidence