反应详情

温度

50 °C

Rac 4 {[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-2-trifluoromethyl-benzoic acid methyl ester (36 mg) was dissolved in MeOH (10 mL). To the stirred solution was added NaOH (1N, 3 mL) and the mixture was stirred at 50° C. for 3 hrs. The solvent was removed and the residue was treated with 1 N HCl to make the mixture acidic. The white suspension was filtered to collect the white solid as the title compound (29 mg, 82% yield).

1. customThe solvent was removed
2. additionthe residue was treated with 1 N HCl
3. filtrationThe white suspension was filtered