Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 53358685 | HCID 53358685 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | HCID 53358569 | HCID 53358569 | — |
Reaction Steps
In a 50 ml pressure tube, (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-N-(5-iodopyridin-2-yl)-5-neopentylpyrrolidine-2-carboxamide (100 mg, 149 μmol, Eq: 1.00) was combined with DMF (4 ml) and water (200 μl). Potassium carbonate (41.3 mg, 299 μmol, Eq: 2) was added. The mixture was bubbled with nitrogen and then palladium(II) acetate (4 mg, 17.8 μmol, Eq: 0.119) was added. The tube was subjected to CO atmosphere at 40 PSI and stirred overnight at 70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08354444B2 |
|---|
| Source dataset | uspto-grants-2013_01 |
|---|
| ORD ID | ord-9b6759e3381f40638828baed60e82ef9 |
|---|
| Source note | uspto-grants-2013_01 |
|---|
