Tetrahydrofuran → HCID 59369749, compound

Participants

Reaction Conditions

Reaction Steps

In a 25 mL round-bottomed flask, methyl 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-2-fluoro-5-methoxybenzoate (80 mg, 123 μmol, Eq: 1.00) was combined with THF (2 ml) and MeOH (4 ml) at 45° C. to give a colorless solution. 1 N NaOH (0.5 ml, 1.00 mmol, Eq: 8.11) was added. The reaction mixture was stirred at 40° C. for 2 hr.

Provenance & Evidence