Potassium Carbonate → HCID 50997448, compound

Participants

Reaction Steps

To a stirred solution of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [1-(3-iodo-phenyl)-ethyl]-methoxy-amide (0.2 g, 0.46 mmol), prepared as described in example P2, in a mixture of ethanol (12 ml) and water (4 ml) was added, 3,4-dichloro-phenyl boronic acid (0.096 g, 0.5 mmol) followed by palladium acetate (0.052 g, 0.23 mmol) and potassium carbonate (0.19 g, 1.38 mmol). It was stirred for 18 hours at ambient temperature. Reaction mass was filtered on celite bed then diluted with water and extracted in ethyl acetate (3×60 ml), washed with water, brine and dried over anhydrous sodium sulfate). The crude mass was purified by column chromatography using 36% Ethyl acetate in hexane to yield 0.12 g (60% of theory) of 3-Difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [1-(3′,4′-dichloro-biphenyl-3-yl)-ethyl]-methoxy-amide in form of a solid. Mp 162-164° C.

Provenance & Evidence