N,N-Dimethylglycine → HCID 50997635, compound

Participants

Reaction Steps

A mixture of 4-chlorophenol (0.2 g, 0.86 mmol) in DMF (2 ml), cesium carbonate (0.7 g, 1.14 mmol), N,N-dimethylglycine (0.01 g, 0.057 mmol), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [1-(3-iodo-phenyl)-ethyl]methoxy-amide (0.25 g, 0.57 mmol), prepared as described in example P2, and Cul (0.09 g, 0.024 mmol) was subjected to microwave irradiation at 90° C. for 20 minutes. Reaction mass was diluted with water and extracted with ethyl acetate (3×60 ml), washed with water, brine and dried over anhydrous sodium sulfate. The crude mass was purified by chromatography to yield 0.057 g (28% of theory) of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[3-(4-chloro-phenoxy)-phenyl]-ethyl}-methoxy-amide in form of a resin.

Provenance & Evidence