Triethylamine → HCID 86761751, compound

Participants

Reaction Steps

To a stirred solution of 4-iodo acetophenone (2.0 g, 8.13 mmol) in methanol (25 ml), O-methyl hydroxyl amine hydrochloride (0.7 g, 8.94 mmole) was added followed by triethyl amine (0.904 g, 8.94 mmol). The reaction mixture was stirred at ambient temperature for 4 hours. Reaction mixture was concentrated under vacuum, residual mass was diluted with water (50 ml) and aq. layer was extracted with ethyl acetate (3×30 ml). Organic layer was washed with water (2×30 ml) followed by brine solution, dried over anhydrous sodium sulfate and evaporated to obtain 2.17 g (97% of theory) of 1-(4-iodo-phenyl)-ethanone O-methyl-oxime.

Provenance & Evidence