Pyridine → HCID 86669068, compound

Participants

Reaction Steps

To a stirred solution of trans 1-[2-(2-chloro-phenyl)-cyclopropyl]-ethanone (1.0 g; 5.1 mmol) in methanol (10 ml) at ambient temperature was added pyridine (0.85 ml; 10 mmol) and methoxyamine hydrochloride (0.86 g; 10 mmol). The reaction mixture was stirred for 16 hours at ambient temperature then poured in water (50 mL) and extracted with dichloromethane (3×30 ml). Combined organic layers were dried over anhydrous sodium sulphate. The solvent was removed in vacuo to afford 1.1 g (98% of theory) of trans 1-[2-(2-chloro-phenyl)-cyclopropyl]-ethanone O-methyl-oxime as an oil.

Provenance & Evidence