Pyridine → HCID 86669070, compound

Participants

Reaction Steps

To a stirred solution of trans 1-[2-(2-Chloro-6-fluoro-phenyl)-cyclopropyl]-ethanone (1.0 g; 4.7 mmol) in methanol (10 ml) at ambient temperature was added pyridine (0.60 ml; 7.0 mmol) and methoxyamine hydrochloride (0.60 g; 7.0 mmol). The reaction mixture was stirred for 16 hours at ambient temperature then poured in water (50 ml) and extracted with dichloromethane (3×30 ml). Combined organic layers were dried over anhydrous sodium sulphate. The solvent was removed in vacuo to afford 1.1 g (100% of theory) of trans 1-[2-(2-Chloro-6-fluoro-phenyl)-cyclopropyl]-ethanone O-methyl-oxime as an E/Z mixture in form of an oil.

Provenance & Evidence