Pyridine → HCID 86669076, compound

Participants

Reaction Steps

To a stirred solution of trans 1-[2-(2,4,5-trichloro-thiophen-3-yl)-cyclopropyl]-ethanone (2.7 g; 10 mmol) prepared as described in example P29, in methanol (20 ml) at ambient temperature was added pyridine (1.25 ml; 15 mmol) and methoxyamine hydrochloride (1.3 g; 15 mmol). The reaction mixture was stirred for 4 hours at ambient temperature then poured in water (50 ml) and extracted with dichloromethane (3×30 ml). Combined organic layers were washed with water (30 ml) and dried over anhydrous sodium sulphate. The solvent was removed in vacuo to afford 2.85 g (95% of theory) of trans 1-[2-(2,4,5-trichloro-thiophen-3-yl)-cyclopropyl]-ethanone O-methyl-oxime as an E/Z mixture in form of an orange oil.

Provenance & Evidence