1-(Triphenylphosphoranylidene)acetone → HCID 67086773, compound

Participants

Reaction Steps

To a stirred solution of 2,4,5-trichloro-thiophene-3-carbaldehyde (10.3 g; 48 mmol) and lithium bromide (0.10 g; 1.2 mmol) in acetonitrile (100 mL) at 15° C. under nitrogen was added acetylmethylene-triphenylphosphorane (15.6 g; 49 mmol). The reaction mixture was stirred for 3 hours at ambient temperature then poured in water (200 ml) and extracted with dichloromethane (3×70 ml). Combined organic layers were dried over anhydrous sodium sulphate. The solvent was removed in vacuo and the residue was purified by chromatography over silica gel (eluant: cyclohexane/ethyl acetate 90:10) to afford 11.2 g (91% of theory) of (E)-4-(2,4,5-trichloro-thiophen-3-yl)-but-3-en-2-one as yellow solid.

Provenance & Evidence