Water → HCID 25044530, compound

Participants

Reaction Steps

2.5 g 5-aminoindole are dissolved in 25 ml of pyridine. To this are added 4.64 g of 3,5-dichlorophenylsulphonyl chloride and the mixture is stirred for 4 hours at ambient temperature. The solvent is eliminated in vacuo and the residue is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are washed with saturated sodium chloride solution. After drying with magnesium sulphate the solvents are eliminated in vacuo and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 10:1 to 1:5).

Provenance & Evidence