反应详情

温度

0 °C

600 mg 1-(2,6-dichloro-phenyl)-1,3-dihydro-indol-2-one are dissolved in 5 ml concentrated sulphuric acid and cooled to 0° C. To this is added dropwise a solution of 160 μl concentrated nitric acid in 1 ml concentrated sulphuric acid. The mixture is stirred for 30 minutes and then added to 50 g ice. Then the mixture is stirred for 1 hour and the solid is suction filtered. After drying in vacuo the solid is chromatographed on silica gel (cyclohexane/ethyl acetate 70:30 to 20:80).

1. stirringThen the mixture is stirred for 1 hour
2. filtrationfiltered
3. customAfter drying in vacuo the solid
4. customis chromatographed on silica gel (cyclohexane/ethyl acetate 70:30 to 20:80)