Hydrochloric Acid → HCID 59276872, compound

Participants

Reaction Steps

230 mg 1-(1H-imidazol-2-yl)-5-nitro-2,3-dihydro-1H-indole are dissolved in 6 ml dimethylformamide, combined with 200 mg potassium carbonate and 75 μl methyl iodide and stirred overnight at ambient temperature. The mixture is divided between ethyl acetate and 2 N hydrochloric acid and the aqueous phase is washed twice with dichloromethane. Then the pH of the aqueous phase is adjusted to 12 by the addition of 40% sodium hydroxide solution and it is extracted with dichloromethane. The organic phase is washed with saturated sodium chloride solution and dried on magnesium sulphate. The solvents are eliminated in vacuo and the residue is chromatographed on silica gel (dichloromethane/methanol 99:1 to 90:10).

Provenance & Evidence