Phosgene → HCID 59277172, compound

Participants

Reaction Steps

385 mg tert. butyl [2-(6-iodo-pyridazin-3-ylamino)-ethyl]-carbamate are dissolved in 10 ml dichloromethane, combined with 360 μl N,N-diisopropyl-N-ethyl-amine and 560 μl of a 20% solution of phosgene in toluene are added dropwise thereto. After stirring overnight the mixture is diluted with ethyl acetate and washed with semisaturated sodium chloride solution. After drying with magnesium sulphate the solvents are eliminated in vacuo and the residue is extracted from diethyl ether.

Provenance & Evidence