HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1807475Generated: October 30, 2026
Benzyl chloroformate → HCID 59205695, compound
https://huagongshe.com/reaction/1807475
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-Aminoisoquinoline | HCID 588991 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59205695 | HCID 59205695 | — |
Reaction Steps
To 6-aminoisoquinoline in DMF at −40° C. was added NaH and solution was warmed to 0° C. for 30 minutes. Then benzylchloroformate was added and the reaction stirred at 0° C. for 2 hours. The solution was quenched with AcOH, poured into NaHCO3(sat) and extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Flash chromatography (SiO2 90% EtOAc/Hex) gave benzylisoquinolin-6-ylcarbamate. (E87).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08357699B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-78b3c9563f17475aa30c769eb444a591 |
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| Source note | uspto-grants-2013_01 |
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